TABLE 2.
Multivariate model for prediction of prevalent (baseline) cirrhosis
| Overall | Age 18 to <40 | Age 40 to <60 | Age ≥60 | |||||
|---|---|---|---|---|---|---|---|---|
| Factor | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p |
| Age (y) | 1.02 (1.02–1.03) | <0.001 | 1.00 (0.98–1.03) | 0.734 | 1.04 (1.02–1.06) | 0.000 | 0.98 (0.97–1.00) | 0.084 |
| Male (vs female) | 1.03 (0.90–1.17) | 0.679 | 1.19 (0.86–1.64) | 0.294 | 0.95 (0.79–1.15) | 0.611 | 1.06 (0.85–1.31) | 0.620 |
| Race | ||||||||
| White | Referent | — | Referent | — | Referent | — | Referent | — |
| Black | 0.35 (0.25–0.49) | <0.001 | 0.58 (0.30–1.12) | 0.103 | 0.32 (0.20–0.51) | <0.001 | 0.27 (0.14–0.53) | <0.001 |
| Asian | 0.42 (0.28–0.64) | <0.001 | 0.45 (0.18–1.12) | 0.085 | 0.53 (0.30–0.93) | 0.027 | 0.36 (0.17–0.77) | 0.009 |
| Hispanic | 0.89 (0.66–1.21) | 0.467 | 0.68 (0.35–1.30) | 0.243 | 1.05 (0.70–1.58) | 0.807 | 1.02 (0.54–1.94) | 0.941 |
| Other | 0.69 (0.48–1.00) | 0.052 | 0.60 (0.24–1.48) | 0.268 | 0.73 (0.43–1.24) | 0.247 | 0.68 (0.36–1.27) | 0.224 |
| Diabetes | 2.44 (2.11–2.82) | <0.001 | 1.74 (1.14–2.66) | 0.011 | 2.75 (2.23–3.39) | <0.001 | 2.17 (1.72–2.74) | <0.001 |
| Hypertension | 0.92 (0.79–1.06) | 0.241 | 1.10 (0.74–1.62) | 0.637 | 0.92 (0.75–1.13) | 0.403 | 0.84 (0.65–1.08) | 0.170 |
| Hyperlipidemia | 0.64 (0.55–0.74) | 0.000 | 0.85 (0.54–1.34) | 0.489 | 0.65 (0.53–0.80) | <0.001 | 0.56 (0.44–0.71) | <0.001 |
| BMI | ||||||||
| Normal | Referent | — | Referent | — | Referent | — | Referent | — |
| Overweight | 0.92 (0.73–1.16) | 0.501 | 0.56 (0.35–0.90) | 0.016 | 1.01 (0.69–1.46) | 0.978 | 1.21 (0.81–1.81) | 0.363 |
| Class 1 obesity | 0.93 (0.74–1.17) | 0.522 | 0.32 (0.19–0.53) | <0.001 | 0.93 (0.64–1.34) | 0.689 | 1.56 (1.05–2.31) | 0.029 |
| Class 2 obesity | 1.08 (0.85–1.37) | 0.542 | 0.36 (0.21–0.61) | <0.001 | 1.23 (0.85–1.79) | 0.271 | 1.61 (1.05–2.46) | 0.029 |
| Class 3 obesity | 1.24 (0.97–1.57) | 0.082 | 0.53 (0.33–0.86) | 0.010 | 1.41 (0.97–2.04) | 0.071 | 1.69 (1.08–2.66) | 0.023 |
| ALT | ||||||||
| <ULN | Referent | — | Referent | — | Referent | — | Referent | — |
| 1 to <2× ULN | 1.25 (1.05–1.50) | 0.013 | 1.32 (0.81–2.16) | 0.269 | 0.99 (0.77–1.29) | 0.968 | 1.45 (1.09–1.93) | 0.010 |
| 2 to <5× ULN | 1.47 (1.21–1.78) | <0.001 | 1.68 (1.03–2.74) | 0.039 | 1.13 (0.86–1.50) | 0.373 | 1.75 (1.27–2.40) | 0.001 |
| ≥5× ULN | 1.91 (1.48–2.45) | <0.001 | 1.75 (0.97–3.18) | 0.064 | 1.83 (1.28–2.62) | 0.001 | 1.92 (1.22–3.02) | 0.005 |
Note: ORs and 95% CI are reported. Normal body mass index was defined as body mass index <23 in Asians and body mass index <25 in non-Asian patients. The upper limit of normal for alanine transaminase was defined as 19 U/L for women or 30 U/L for men.
Abbreviations: ALT, alanine transaminase; BMI, body mass index; ULN, upper limit of normal.