TABLE 1.

Assessment of serologic response to ursodeoxycholic acid

Serologic response to UDCA therapy in PBC
	Treatment duration (mo)	Treatment failure if
Rochester	6	ALP ≥ 2× ULN or Mayo score ≥4.5
Barcelona	12	Decrease in ALP ≤ 40% and ALP ≥ 1× ULN
Paris I	12	ALP ≥ 3× ULN or AST ≥ 2× ULN or bilirubin > 1 mg/dL
Rotterdam	12	Bilirubin > 1 mg/dL and/or albumin < 1× ULN
Toronto	24	ALP ≥ 1.67× ULN
Paris-II	12	ALP ≥ 1.5× ULN or AST ≥ 1.5× ULN or bilirubin > 1 mg/dL
Ehime	6	Decrease in GGT ≤ 70% and GGT ≥ 1× ULN
Rochester-II	12	ALP 2× ULN
Global	12	ALP 2× ULN

Abbreviations: ALP, alkaline phosphatase; AST, aspartate aminotransferase; GGT, gamma-glutamyl transferase; ULN, upper limit of normal.