Table 1.
Effect of S. striata aqueous (SSAE) and hydroalcoholic (SSHE) extracts on macroscopic parameters of colitis in rats
| Groups/dose (mg/kg) | Ulcer aera (cm2) (0-8) | Ulcer score (0-4) | Ulcer index (0-12) | Colon/height (g/cm) |
|---|---|---|---|---|
| Normal | 0.00±0.00 | 0.00±0.00 | 0.00±0.00 | 0.10±0.02 |
| Control colitis | 7.46±1.02### | 3.66±0.40 ### | 11.12±1.81### | 0.22±0.04### |
| SSAE 150 | 3.82±0.68** | 3.00±0.38 | 6.82±1.51* | 0.14±0.02* |
| SSAE 300 | 4.29±1.14* | 2.33±0.22* | 6.62±1.36* | 0.13±0.03* |
| SSAE 600 | 2.71±1.03** | 2.16±0.23* | 4.87±1.23** | 0.10±0.02** |
| SSHE 150 | 1.48±0.50*** | 1.66±0.16** | 3.14±0.39*** | 0.09±0.02** |
| SSHE 300 | 1.29±0.65*** | 1.33±0.18 *** | 2.62±1.19*** | 0.09±0.02** |
| SSHE 600 | 0.45±0.16***,+ | 0.66±0.20 ***,+ | 1.11±0.68***,+ | 0.08±0.01*** |
| Dex. 1 | 0.42±0.12*** | 0.5±0.28*** | 0.92±0.46*** | 0.07±0.01*** |
| Mes. 100 | 3.04±0.71** | 1.33±0.30** | 4.37±1.2** | 0.11±0.01** |
Data are presented as Mean±standard error of mean (n=6). Dex. (Dexamethasone), Mes. (Mesalazine). The differences between groups were calculated based on ANOVA and Mann-Whitney tests. *P<0.05, **P<0.01, and ***P<0.001 represent significant difference compared to control group, +P<0.05 represent significant difference compared to SSAE 600 mg/kg, ###P<0.001: represent significant difference compared to normal group