Table 3.

GRADE Evidence profile/summary of findings table for individual predictors and models of mechanical ventilation, functional outcome, and independent ambulation

Outcome	Predictor	Quality of Evidence					Summary of findings (narrative of effect size)
		RoB	Inconsistency	Indirectness	Imprecision	QoE summary
Mechanical ventilation	Bulbar weakness	↓		↓	↓	Very low	OR ranging from 1.96 to 48.08 (of note, large 95% CI); in some studies, facial-bulbar not separated/cranial nerve dysfunction and bulbar weakness used interchangeably
Mechanical ventilation	Degree of motor weakness (limb strength less than antigravity, MRC grade) on admission or nadir	↓			↓	Low	OR ranging from 2.5 to 87 (of note, large 95% CI) depending on threshold for MRC sum score
Mechanical ventilation	Rapid disease progression	↓		↓	↓	Very low	OR estimates not consistently performed; ranging from 1.68 to 25; different definition of rapid progression
Mechanical ventilation	Neck weakness	↓	↓	↓	↓	Very low	OR 4.34 to 9.86 (large 95% CI)
Mechanical ventilation	Autonomic dysfunction	↓↓	↓		↓	Very low	Variable definition of autonomic dysfunction
Mechanical ventilation	EGRIS	↓				Moderate	AUC 0.82; in another validation cohort, AUC was 0.86 (0.80–0.93). Lowest AUC reported 0.63
Mechanical ventilation	Sharshar Score	↓			↓	Low	AUC 0.81 (0.72–0.90) Only one validation study
Mechanical ventilation	New normogram	↓			↓	Low	AUC 0,85, C-index 0.86 (95% CI 0.77–0.94) Only one validation study
Functional outcome	Need for mechanical ventilation	↓	↓			Low	OR 2.5–16 (for poor outcome)
Functional outcome	Axonal electrophysiologic subtype	↓	↓		↓	Very low	OR 2–14.45
Functional outcome	Age	↓			↓	Low	OR 1.3–10.3 (dependent on age categories or per year)
Functional Outcome	Disability grade at nadir	↓			↓	Low	OR 2.9–8.88, variable scales used to assess both intake and outcome
Independent ambulation	Disability grade at nadir (MRC sum score, GBSD score)	↓			↓	Low	OR to 3–4 for MRC sum score > 40
Independent ambulation	Age	↓			↓	Low	OR 1.08–3.8 (dependent on age categories or per year)
Independent ambulation	Progression of weakness (speed)	↓		↓	↓	Very low	OR 3.8–8.6 (for poor outcome)
Independent ambulation	EGOS	↓				Moderate	AUC 0·85, 95% CI 0·81–0·89
Independent ambulation	mEGOS	↓				Moderate	after 1 week AUC 0.84–0.87 and at admission the AUC is 0.73–0.77. In another validation cohort, the AUC was 0.75 (0.70–0.80) after 1 week and 0.74 (0.69–0.79) at admission

OR Odds ratio; CI Confidence interval; MRC Medical research council; EGRIS Erasmus Guillain Barré Syndrome Respiratory Insufficiency score; AUC Area under the curve; EGOS Erasmus Guillain Barré Syndrome Outcome Score; mEGOS modified Erasmus Guillain Barré Syndrome Outcome Score