. 2023 Apr 3;5(2-3):122–129. doi: 10.1007/s44228-023-00037-7

Table 2.

Fludarabine dose recommendation in patients with renal insufficiency

Author/references	Dose reduction
Bodge et al. [40]	20–25% reduction for GFR between 45–89 ml/min/1.73m² 50% reduction for GFR between 44–29 ml/min/1.73m² and those on HD *based on KDIGO guidelines
Golightly et al. [41]	20% reduction CrCl 50–79 mL/min 40% reduction CrCl 30–49 mL/min Do not administer for CrCl < 30 mL/min
Aronoff et al. [42]	25% reduction for CrCl 10–50 mL/min 50% reduction for CrCl < 10 mL/min

Author/references

Dose reduction

Bodge et al. [40]

20–25% reduction for GFR between 45–89 ml/min/1.73m²

50% reduction for GFR between 44–29 ml/min/1.73m² and those on HD

*based on KDIGO guidelines

Golightly et al. [41]

20% reduction CrCl 50–79 mL/min

40% reduction CrCl 30–49 mL/min

Do not administer for CrCl < 30 mL/min

Aronoff et al. [42]

25% reduction for CrCl 10–50 mL/min

50% reduction for CrCl < 10 mL/min

CrCl Creatinine clearance, GFR Glomerular filtration rate, HD Hemodialysis *KDIGO Kidney Disease Improving Global Outcome