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. 2023 Jun 5;14:3239. doi: 10.1038/s41467-023-38994-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a–d Violin plots with allele-dependent differences in expression of NOD1, CASP1, PPP3CA, and CD86 in A. fumigatus (Af), N. meningitidis (Nm) or S. aureus (Sa) stimulated monocytes following 6 h treatment. Distribution of centralized log₂ expression is shown for genotypes of indicated single-nucleotide polymorphisms (SNPs). Dashed lines: regression slope of gene expression values vs. genotype. Dots: individuals for the respective genotype. Horizontal lines in violins indicate 75th percentile, median and 25th percentile from top to bottom. For NOD1 and CD86, only the top SNP for a condition with the strongest p value is shown. e Allele-dependent differences in expression of ITGAX with opposite effect directions after stimulation with N. meningitidis compared to A. fumigatus (p_Nm-Af = 2.63 × 10⁻¹⁷) and S. aureus (p_Nm-Sa = 2.33 × 10⁻²²) for 6 h. Bonferroni corrected p-values from z test of differences in regression coefficients to unstimulated control (ctrl) are indicated. Ctrl: unstimulated. Source data are provided as a Source Data file.