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. 2023 Jun 5;14:3239. doi: 10.1038/s41467-023-38994-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Disease-associated genome-wide association study single-nucleotide polymorphisms (GWAS-SNPs) in high linkage disequilibrium (LD) (r² > 0.8) with response expression quantitative trait loci (reQTL) in pathogen-exposed monocytes. reQTL-regulated genes are connected to diseases by lines. Inserted table lists reQTL-regulated genes connected to only one disease. Colors: exposure to different pathogens. b–d Allele-dependent differences in expression of NIPAL4, IRF8 and TNFRSF10A following pathogen exposure. Corresponding reQTLs are in LD with GWAS-SNPs for b psoriasis, c primary biliary cholangitis, inflammatory bowel disease, systemic lupus erythematosus, multiple sclerosis or d age-related macular degeneration. For IRF8 and TNFRSF10A only the top SNP for one condition with strongest p-value is shown. Ctrl: unstimulated, Af: A. fumigatus, Nm: N. meningitidis, Sa: S. aureus. Bonferroni corrected p values from z test of differences in regression coefficients to unstimulated control (ctrl) are indicated. List of disease-associated GWAS-SNPs with reQTL effects in stimulated monocytes with all associations of reQTLs and GWAS diseases and disease abbreviations is provided in Supplementary Data 7. Source data are provided as a Source Data file.