Table 1.
Tumour and patient characteristics in Cohort 1 and their association with tumour necrosis.
| Characteristic | Total N (%) | Tumour necrosis percentage | |||||
|---|---|---|---|---|---|---|---|
| <3% | 3–9.9% | 10–39.9% | ≥40% | P value | |||
| All cases | 1100 (100%) | 104 (9.5%) | 593 (54%) | 341 (31%) | 62 (5.6%) | ||
| Sex | Male | 557 (51%) | 51 (9.2%) | 304 (55%) | 171 (31%) | 31 (5.6%) | 0.97 |
| Female | 543 (49%) | 53 (9.8%) | 289 (53%) | 170 (31%) | 31 (5.7%) | ||
| Age | <65 | 290 (26%) | 23 (7.9%) | 149 (51%) | 99 (34%) | 19 (6.6%) | 0.58 |
| 65–75 | 381 (35%) | 35 (9.2%) | 215 (56%) | 109 (29%) | 22 (5.8%) | ||
| >75 | 429 (39%) | 46 (11%) | 229 (53%) | 133 (31%) | 21 (4.9%) | ||
| Tumour location | Proximal colon | 536 (49%) | 63 (12%) | 284 (53%) | 158 (29%) | 31 (5.8%) | 0.0001 |
| Distal colon | 404 (37%) | 24 (5.9%) | 205 (51%) | 146 (36%) | 29 (7.1%) | ||
| Rectum | 160 (15%) | 17 (11%) | 104 (65%) | 37 (23%) | 2 (1.3%) | ||
| T | T1 | 58 (5.3%) | 13 (22%) | 34 (59%) | 11 (19%) | 0 (0%) | <0.0001 |
| T2 | 169 (15%) | 24 (14%) | 108 (64%) | 37 (22%) | 0 (0%) | ||
| T3 | 677 (62%) | 52 (7.7%) | 370 (55%) | 221 (33%) | 34 (5%) | ||
| T4 | 196 (18%) | 15 (7.7%) | 81 (41%) | 72 (37%) | 28 (14%) | ||
| N | N0 | 626 (57%) | 71 (11%) | 361 (58%) | 171 (27%) | 23 (3.7%) | 0.0002 |
| N1 | 275 (25%) | 18 (6.5%) | 139 (51%) | 95 (35%) | 23 (8.4%) | ||
| N2 | 199 (18%) | 15 (7.5%) | 93 (47%) | 75 (38%) | 16 (8.0%) | ||
| M | M0 | 947 (86%) | 93 (9.8%) | 519 (55%) | 288 (30%) | 47 (5.0%) | 0.042 |
| M1 | 153 (14%) | 11 (7.2%) | 74 (48%) | 53 (35%) | 15 (9.8%) | ||
| Stage | I | 184 (17%) | 29 (16%) | 119 (65%) | 36 (20%) | 0 (0%) | <0.0001 |
| II | 408 (37%) | 40 (9.8%) | 219 (54%) | 126 (31%) | 23 (5.6%) | ||
| III | 355 (32%) | 24 (6.8%) | 181 (51%) | 126 (35%) | 24 (6.8%) | ||
| IV | 153 (14%) | 11 (7.2%) | 74 (48%) | 53 (35%) | 15 (9.8%) | ||
| WHO grade | Low grade | 903 (82%) | 78 (8.6%) | 501 (55%) | 284 (31%) | 40 (4.4%) | 0.0003 |
| High grade | 197 (18%) | 26 (13%) | 92 (47%) | 57 (29%) | 22 (11%) | ||
| Glasgow Microenvironment Score | GMS0 | 469 (43%) | 52 (11%) | 288 (61%) | 119 (25%) | 10 (2.1%) | <0.0001 |
| GMS1 | 329 (30%) | 37 (11%) | 163 (50%) | 106 (32%) | 23 (7.0%) | ||
| GMS2 | 302 (27%) | 15 (5.0%) | 142 (47%) | 116 (38%) | 29 (9.6%) | ||
| MMR enzyme status | Proficient | 931 (85%) | 77 (8.3%) | 513 (55%) | 293 (31%) | 48 (5.2%) | 0.004 |
| Deficient | 169 (15%) | 27 (16%) | 80 (49%) | 48 (28%) | 14 (8.3%) | ||
| BRAF statusa | Wild-type | 916 (83%) | 76 (8.3%) | 497 (54%) | 293 (32%) | 50 (5.5%) | 0.017 |
| Mutant | 182 (17%) | 28 (15%) | 94 (52%) | 48 (26%) | 12 (6.6%) | ||
aData missing from two patients.