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. 2023 Apr 4;128(12):2175–2185. doi: 10.1038/s41416-023-02235-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a–d Kaplan–Meier survival curves for progression-free survival (PFS) in all 316 patients according to the density of total TLSs (a), E-TLSs (b), PFL-TLSs (c), and SFL-TLSs (d). e–g Subgroup analysis of Kaplan–Meier survival curves for PFS according to total TLS density among Stage I (e), Stage II (f) and Stage III–IV (g) patients. Comparisons were made by the log-rank test. The hazard ratio (HR) and 95% confidence intervals were computed by a Cox proportional hazard model.