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. 2023 Apr 4;128(12):2175–2185. doi: 10.1038/s41416-023-02235-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Representative images of each TLS maturation category, showing DCs (CD1c, light blue), CD4 T cells (CD4, yellow), CD8 T cells (CD8, orange), B cells (CD19, red), follicular DCs (CD21, green), plasma cells (CD138, purple) and DAPI. b Total cell counts in high-power field (HPF) based on TLS maturation category. c Composition of six immune cell subsets in TLSs according to each maturation category. d Proportion of CD138⁺ plasma cells in TLSs according to each maturation category. Scale bars = 200 µm. Comparisons were made by Mann–Whitney U test.