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. 2023 Apr 4;128(12):2175–2185. doi: 10.1038/s41416-023-02235-9

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© The Author(s) 2023

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Fig. 4 — a Scheme of treatment course and CT/PET-CT images of target lesions (white arrowheads), and H&E images of TLS (yellow arrowheads) in whole tumour sections from a representative responder (left) and non-responder (right) to anti-PD-1 antibody. b TLS density according to pT in recurrent oesophageal cancer patients treated with anti-PD-1 antibody. c, d TLS density according to two (c) and four (d) categories of response to anti-PD-1 antibody. e Comparison of TLS maturity according to response to anti-PD-1 antibody. Red lines and the numbers next to them show median. f Kaplan–Meier survival curve of PFS according to TLS density in resected specimens from prior surgery. Comparisons were made by Mann–Whitney U test for continuous variables, and a log-rank test for survival analysis.