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. 2023 Apr 12;128(12):2295–2306. doi: 10.1038/s41416-023-02240-y

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© The Author(s) 2023, corrected publication 2023

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Fig. 2 — Two four-tiered grading systems were investigated, both based on tumour classification as CDG1, CDG2 and CDG3 and an additional split of the CDG2 class. a, b The set of CDG2 tumours was split based on the number of budding foci. Hazard ratios compared to CDG1 tumours increased and reached 1.5, 2.1, and 2.5 for CDG2/weak TB, CDG2/moderate TB and CDG3 tumours. c, d The set of CDG2 tumours was split based on the presence or absence of single-cell invasion (SCI). Counterintuitively, CDG2 tumours without SCI showed a (non-significant) trend to unfavourable prognosis compared to CDG2 tumours with SCI. e Relation between the number of budding foci, the classification of TB, and the CDG systems.