REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-Rabbit monoclonalAnti-PHF6	Sigma	Cat# HPA001023; RRID: AB_1079606
Anti-Rabbit monoclonal anti-GAPDH	Cell Signaling Technology	Cat#: CST2118
Anti-mouse CD45.1 (APC)	Invitrogen	Cat#: 17-0453-82; RRID: AB_469398
Anti-mouse CD45.1 (APC-Cy7)	Biolegend	Cat#: 560579
Anti-mouse CD45.1 (Percp-Cy5.5)	Invitrogen	Cat#: 45-0453-82
Anti-mouse CD45.2 (PE)	eBioscience	Cat#: 12-0454-83; RRID: AB_465679
Anti-mouse CD45.2 (Percp-Cy5.5)	eBioscience	Cat#: 45-0453-82; RRID: AB_953590
Anti-mouse CD3 (PE)	eBioscience	Cat#: 12-0454-83; RRID: AB_465679
Anti-mouse CD3 (FITC)	Biolegend	Cat#: 100204
Anti-mouse CD3 (Biotin)	Invitrogen	Cat#: 13-0032-82; RRID: AB_2572762
Anti-mouse CD11b (Mac-1) (APC-Cy7)	Biolegend	Cat#: 101226
Anti-mouse CD11b (Mac-1) (Alexa Fluor780)	Invitrogen	Cat#: 47-0112-82; RRID: AB_1603193
Anti-mouse B220 (CD45R) (PerCP-Cyanine5.5)	eBioscience	Cat#: 45-0452-82; RRID: AB_1107006
Anti-mouse B220 (CD45R) (Biotin)	eBioscience	Cat#: 36-0452-85; RRID: AB_469753
Anti-mouse CD135 (Flk2) (PE)	eBioscience	Cat#: 12-1351-82
Anti-mouse Ly-6G (Gr-1) (Biotin)	eBioscience	Cat#: 13-5931-85; RRID: AB_466801
Anti-mouse CD34 (FITC)	Invitrogen	Cat#: 11-0341-82; RRID: AB_465021
Anti-mouse Ter119 (Biotin)	Invitrogen	Cat#: 13-5921-85; RRID: AB_466798
Anti-mouse CD16/32 (APC)	eBioscience	Cat#: 17-0161-82; RRID: AB_469356
Anti-mouse CD16/32 (FITC)	eBioscience	Cat#: 11-0161-82; RRID: AB_464956
Anti-mouse CD127 (IL-7R) (PE)	Invitrogen	Cat#: 12-1271-82
Anti-mouse CD44 (PE)	eBioscience	Cat#: 12-0441-82; RRID: AB_465664
Anti-mouse CD4 (PE-Cy7)	eBioscience	Cat#: 25-0041-82; RRID: AB_469576
Anti-mouse CD4 (Biotin)	eBioscience	Cat#: 13-0043-85; RRID: AB_466334
Anti-mouse CD8a (APC)	Biolegend	Cat#: 100712
Anti-mouse CD8a (Biotin)	eBioscience	Cat#: 13-0081-85; RRID: AB_466347
Anti-mouse Streptavidin (APC)	Biolegend	Cat#: 405207
Anti-mouse Streptavidin (APC-eFlour 780)	Invitrogen	Cat#: 47-4317-82; RRID: AB_10366688
Anti-mouse Sca-1 (PE)	Invitrogen	Cat#: MA5-17890
Anti-mouse Sca-1 (PE-Cy7)	Invitrogen	Cat#: 25-5918-81
Anti-mouse c-Kit (APC)	Invitrogen	Cat#: 17-1171-82; RRID: AB_469430
Anti-mouse c-Kit (PE)	Invitrogen	Cat#: 12-1171-82; RRID: AB_465813
Anti-mouse c-Kit (PE-Cy7)	Invitrogen	Cat#: 25-1178-42; RRID: AB_10718535
Anti-mouse CD25 (APC-Cy7)	Biolegend	Cat#: 557658
Anti-mouse CD69 (PE)	eBioscience	Cat#: 12-0691-82; RRID: AB_465732
Anti-mouse CD48 (FITC)	eBioscience	Cat#: 11-0481-82; RRID: AB_465077
Anti-mouse CD150 (PE-Cy7)	eBioscience	Cat#: 25-1502-82; RRID: AB_10805742
Anti-Mouse IFNγ (PE)	eBioscience	Cat#: 12-7319-81; RRID: AB_1272169
Anti-Mouse TNFα (FITC)	eBioscience	Cat#: 11-7349-82; RRID: AB_465424
Annexin V	Biolegend	Cat#: 640908
Chemicals, peptides, and recombinant proteins
TRIzol™ Reagent	Invitrogen	Cat#: 15596026CN
Fast SYBR Green Master Mix	Clontech	Cat#: 639676
Mouse CD117 MicroBeads	Miltenyi Biotec	Cat#130-091-224
DreamTaq Green PCR Master Mix	Thermo Fisher	Cat#: K1082
DAPI	Invitrogen	Cat#D1306
Critical commercial assays
DNeasy Blood & Tissue Kit	Qiagen	Cat#: 69506
Lineage Cell Depletion Kit	Miltenyi Biotec	Cat#: 130-110-470
TransScript® All-in-One First-Strand cDNA Synthesis SuperMix for qPCR	Trans	Cat#: AT341-01
T Cell Activation/Expansion Kit	Miltenyi Biotec	Cat#: 130-093-627
Deposited data
RNA-seq	NOVOGENE	GEO: GSE201475
Experimental models: Organisms/strains
Mouse: C57BL/6J	The Model Organisms Center, Inc	N/A
Mouse: B6.SJL	The Model Organisms Center, Inc	N/A
Mouse: Vav1-Cre	The Model Organisms Center, Inc	N/A
Mouse: Phf6fl-R274X	The Model Organisms Center, Inc	N/A
Oligonucleotides
qPCR primers see Table S1	This study	N/A
Software and algorithms
GraphPad Prism 8	This study	N/A
FlowJo	This study	N/A
Adobe Illustrator 2021	This study	N/A
DESeq2 R package	This study	N/A