Table 4.

Predictive model performance for Ki-67 in the internal and external test.

Models	Features/classification	Test	Accuracy	95% CI	AUC	95% CI	Sensitivity	95% CI	Specificity	95% CI
Radiomics	Lasso+RandomForest	Internal test	0.813	0.73 - 0.89	0.756	0.666 - 0.845	0.576	0.407 - 0.75	0.936	0.876 - 0.986
		External test	0.751	0.669 - 0.83	0.677	0.567 - 0.778	0.516	0.322 - 0.708	0.837	0.753 - 0.917
	Lasso+LDA	Internal test	0.813	0.74 - 0.88	0.756	0.669 - 0.841	0.576	0.405 - 0.741	0.937	0.873 - 0.985
		External test	0.753	0.66 - 0.83	0.679	0.582 - 0.779	0.518	0.344 - 0.708	0.839	0.753 -0.921
	LinearSVC+RandomForest	Internal test	0.796	0.71 - 0.87	0.721	0.634 - 0.81	0.487	0.31 - 0.656	0.955	0.901 - 1
		External test	0.751	0.67 - 0.83	0.615	0.526 - 0.719	0.317	0.142 - 0.5	0.913	0.845 - 0.972
	LinearSVC+LDA	Internal test	0.795	0.71 - 0.87	0.72	0.636 - 0.811	0.486	0.323 - 0.648	0.954	0.898 - 1
		External test	0.753	0.67 - 0.83	0.616	0.526 - 0.708	0.321	0.156 - 0.5	0.91	0.845 - 0.972
	ExtraTree+RandomForest	Internal test	0.773	0.689 - 0.85	0.733	0.636 - 0.821	0.608	0.448 - 0.769	0.857	0.765 - 0.94
		External test	0.783	0.7 - 0.86	0.698	0.603 - 0.796	0.515	0.333 - 0.694	0.882	0.8 - 0.946
	ExtraTree+LDA	Internal test	0.771	0.69 - 0.85	0.729	0.635 - 0.822	0.6	0.428 - 0.766	0.859	0.77 - 0.937
		External test	0.785	0.7 - 0.87	0.7	0.598 - 0.811	0.518	0.32 - 0.718	0.882	0.807 - 0.951
Clinics+ Radiomics	Lasso+RandomForest	Internal test	0.867	0.81 - 0.93	0.82	0.741 - 0.897	0.671	0.514 - 0.821	0.969	0.923 - 1
		External test	0.743	0.66 - 0.82	0.712	0.611 - 0.808	0.643	0.45 -0.809	0.78	0.684 - 0.875
	Lasso+LDA	Internal test	0.866	0.79 - 0.93	0.817	0.727 - 0.896	0.665	0.499 - 0.818	0.968	0.919 - 1
		External test	0.777	0.69 - 0.85	0.67	0.569 - 0.771	0.441	0.25 - 0.631	0.899	0.823 - 0.96
	LinearSVC+RandomForest	Internal test	0.846	0.77 - 0.91	0.796	0.705 - 0.88	0.639	0.47 - 0.8	0.953	0.893 - 1
		External test	0.732	0.64 - 0.82	0.628	0.534 - 0.74	0.403	0.217 - 0.613	0.854	0.774 - 0.925
	LinearSVC+LDA	Internal test	0.847	0.77 - 0.91	0.796	0.705 - 0.881	0.639	0.468 - 0.794	0.953	0.892 - 1
		External test	0.731	0.64 - 0.81	0.626	0.516 - 0.725	0.398	0.206 - 0.577	0.854	0.767 - 0.931
	ExtraTree+RandomForest	Internal test	0.815	0.74 - 0.89	0.757	0.67 - 0.843	0.576	0.407 - 0.743	0.938	0.876 - 0.985
		External test	0.773	0.68 - 0.85	0.666	0.562 - 0.767	0.435	0.25 - 0.629	0.896	0.823 - 0.96
	ExtraTree+LDA	Internal test	0.815	0.74 - 0.89	0.758	0.663 - 0.838	0.578	0.4 - 0.736	0.937	0.873 - 0.985
		External test	0.744	0.66 - 0.83	0.713	0.614 - 0.82	0.644	0.444 - 0.826	0.781	0.684 - 0.873