Table 5.

Predictive model performance for p53 in the internal and external test.

Models	Features/classification	Test	Accuracy	95% CI	AUC	95% CI	Sensitivity	95% CI	Specificity	95% CI
Radiomics	Lasso+RandomForest	Internal test	0.731	0.649 - 0.81	0.729	0.642 0.815	0.743	0.618 - 0.84	0.715	0.585 - 0.842
		External test	0.631	0.54 - 0.73	0.614	0.516 - 0.71	0.506	0.355 - 0.666	0.722	0.599 - 0.828
	Lasso+LDA	Internal test	0.731	0.65 - 0.82	0.728	0.644 - 0.811	0.744	0.627 - 0.854	0.713	0.584 - 0.837
		External test	0.636	0.55 - 0.74	0.619	0.527 - 0.717	0.516	0.357 - 0.681	0.721	0.599 - 0.839
	LinearSVC+RandomForest	Internal test	0.71	0.62 - 0.8	0.719	0.635 - 0.803	0.653	0.534 - 0.769	0.786	0.666 - 0.895
		External test	0.657	0.57 - 0.75	0.637	0.547 - 0.726	0.515	0.365 - 0.657	0.759	0.655 - 0.866
	LinearSVC+LDA	Internal test	0.71	0.62 - 0.8	0.719	0.63 - 0.806	0.654	0.523 - 0.775	0.783	0.653 - 0.894
		External test	0.657	0.56 - 0.74	0.636	0.542 - 0.733	0.509	0.361 - 0.666	0.763	0.655 - 0.866
	ExtraTree+RandomForest	Internal test	0.659	0.56 - 0.75	0.656	0.559 - 0.751	0.674	0.546 - 0.792	0.639	0.499 - 0.772
		External test	0.733	0.64 - 0.82	0.692	0.611 - 0.777	0.437	0.292 - 0.589	0.946	0.88 - 1
	ExtraTree+LDA	Internal test	0.657	0.56 - 0.75	0.655	0.556 - 0.743	0.672	0.538 - 0.793	0.638	0.477 - 0.777
		External test	0.73	0.64 - 0.82	0.69	0.612 - 0.773	0.435	0.285 - 0.593	0.944	0.883 - 1
Clinics+ Radiomics	Lasso+RandomForest	Internal test	0.857	0.79 - 0.92	0.858	0.786 - 0.921	0.877	0.759 - 0.944	0.894	0.755 - 0.95
		External test	0.731	0.64 - 0.81	0.7	0.615 - 0.767	0.436	0.294 - 0.581	0.944	0.872 - 1
	Lasso+LDA	Internal test	0.854	0.789 - 0.92	0.856	0.782 - 0.924	0.851	0.758 - 0.947	0.855	0.736 - 0.954
		External test	0.719	0.64 - 0.8	0.683	0.603 - 0.767	0.458	0.314 - 0.6	0.908	0.823 - 0.967
	LinearSVC+RandomForest	Internal test	0.794	0.71 - 0.87	0.793	0.704 - 0.869	0.8	0.689 - 0.896	0.787	0.644 - 0.902
		External test	0.71	0.62 - 0.8	0.683	0.593 - 0.767	0.516	0.355 - 0.666	0.85	0.75 - 0.938
	LinearSVC+LDA	Internal test	0.793	0.72 - 0.88	0.792	0.712 - 0.871	0.8	0.685 - 0.91	0.784	0.655 - 0.9
		External test	0.707	0.619 - 0.8	0.678	0.585 - 0.77	0.506	0.349 - 0.659	0.85	0.759 - 0.933
	ExtraTree+RandomForest	Internal test	0.782	0.7 - 0.87	0.782	0.693 - 0.869	0.779	0.666 - 0.883	0.784	0.651 - 0.913
		External test	0.718	0.63 - 0.8	0.684	0.601 - 0.763	0.462	0.319 - 0.609	0.905	0.83 - 0.98
	ExtraTree+LDA	Internal test	0.786	0.7 - 0.87	0.785	0.7 - 0.871	0.784	0.677 - 0.889	0.788	0.659 - 0.9
		External test	0.73	0.65 - 0.81	0.689	0.609 - 0.767	0.433	0.289 - 0.575	0.945	0.875 - 1