Table 1.
Age at diagnosis of endometriosis-associated ovarian cancer – a summary of cohort studies.
| Study | No. of women | Country | Study methodology | Study period (years) |
Age (years) Mean +/- SD | Age range (years) |
Notes | Cancer arising from ovarian endometriosis |
|---|---|---|---|---|---|---|---|---|
| Hernández et al., 2022 (23) | 17 | Spain | Retrospective observational | 3 | Median 50 | Interquartile 43-63 | All with EAOC | Yes |
| Huang et al., 2022 (24) | 57 | Taiwan | Retrospective cooperative | 3 | 53.1 ± 9.3 | ND | All with CCOC 47/57 cases associated with endometriosis | Yes |
| So et al., 2021 (44) | 12 | South Korea | Retrospective | 17 | 36.3 ± 5.2 | 29-56 | All with EAOC | Yes |
| Zhang et al., 2021 (47) | 14 | China | Retrospective comparative | 9 | 47.1 ± 11.0 | ND | All with EAOC | Yes |
| Zhou et al., 2021 (46) | 114 | China | Retrospective | 21 | 51.1 ± 9.0 | 24–79 | All with EAOC | ND |
| Zhu et al., 2021 (45) | 16 | China | Retrospective | 10 | 45.5 ± 6.2 | 35-54 | All with CCOC associated with endometriosis | Yes |
| Udomsinkul et al., 2020 (20) | 79 | Thailand | Retrospective case-control | 16 | Median 49 | Interquartile 44-54 | All with EAOC | Yes |
| Li et al., 2019 (25) | 34 | China | Retrospective comparative | 17 | 48.7 ± 9.0 | 32-63 | All with EAOC | Yes |
| Son et al., 2019 (44) | 35 | South Korea | Retrospective comparative | 17 | Median 47 | 33-60 | All with CCOC associated with endometriosis | Yes |
| Bassiouny et al., 2018 (29) | 168 | Canada | Retrospective comparative | 13 | 56.6 ± 11.5 | ND | All with EAOC | Yes |
| Yamamoto et al., 2018 (43) | 28 | Japan | Retrospective comparative | 4 | 53.1 ± 14.5 | ND | All with EAOC | Yes |
| Moro et al., 2018 (27) | 49 | European countries | Retrospective multicenter | 17 | Median 53 | 26-86 | All with EOC associated with endometriosis | Yes |
| Muangtan et al., 2018 (42) | 32 | Thailand | Retrospective comparative | 5 | 51.4 ± 10.1 | ND | All with EAOC | Yes |
| Pozzati et al., 2018 (28) | 24 10 20 |
European countries | Retrospective multicenter | 17 | Median 47.5 Median 55.0 Median 55.0 |
32-72 37-80 35-70 |
All with CCOC associated with endometriosis | Yes Yes No |
| Paik et al., 2018 (41) | 41 | South Korea | Retrospective comparative | 15 | 45.1 ± 7.0 | ND | All with EAOC | Yes |
| Park et al., 2018 (40) | 78 | South Korea | Retrospective comparative | 22 | Median 48 | 29-69 | All with CCOC associated with endometriosis | Yes |
| Tanase et al., 2018 (39) | 40 | Japan | Retrospective comparative | 8 | 54.3 ± 8.9 | 39-75 | All with EAOC | Yes |
| Kuo et al., 2017 (38) | 11 | Thailand | Retrospective | 10 | 44.7 ± 3.2 | 40-52 | All with EAOC | Yes |
| Bounus et al., 2016 | 45 | Italy | Retrospective comparative | 10 | 59.0 ± 9.6 | ND | All with EAOC | No 34/45 of cases had extra-gonadal endometriosis |
| Dinkelspiel et al., 2016 (36) | 49 | USA | Retrospective comparative | 14 | Mean 52 Median 52 |
47-57 | All with EAOC | Yes |
| Acién et al., 2015 (35) | 20 | Spain | Retrospective comparative | 20 | 48.8 ± 11.6 | 32-72 | All with EAOC | No |
| Akbarzadeh-Jahromi et al., 2015 (34) | 28 | Iran | Retrospective multi-center | 6 | 49.9± 9.4 | 29-72 | All with EAOC | No Included cases with extra-gonadal endometriosis |
| Scarfone et al., 2014 (33) | 27 | Italy | Retrospective comparative | 22 | 51.4 ± 10.0 | 30-71 | All with CCOC associated with endometriosis | Yes |
| Wang et al., 2013 (21) | 17 | China | Retrospective comparative | 1 | 46.1 ± 10.1 | 33-66 | All with EAOC | No Included cases with extra-gonadal endometriosis |
| Kondi-Pafiti et al., 2012 | 17 | Greece | Retrospective | 10 | Median 58 | 26-76 | All with EAOC | Yes |
ND - not disclosed; EAOC - endometriosis-associated ovarian cancer; CCOC - clear-cell ovarian cancer; EOC - endometrioid ovarian cancer.