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. 2023 May 23;10:1130625. doi: 10.3389/fmolb.2023.1130625

TABLE 1.

GLP-1 Receptor Agonists vs. DPP-4 inhibitors.

Parameter GLP-1 receptor agonists DPP-4 inhibitors
Total cholesterol Stimulate effective reduction Minor reduction only
Weight control Weight loss Weight neutral
Safety profile Gastrointestinal side-effects such as nausea. Well tolerated
Mode of administration As injectable peptides (Except for oral form of semaglutide) Small agents can be taken orally