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. 2023 May 23;14:1186397. doi: 10.3389/fpsyt.2023.1186397

Figure 3.

Figure 3

Tianeptine-induced hyperlocomotor effect is MOR-dependent, and chronic administration of tianeptine induces tolerance to this effect. (A) Cumulative doses of tianeptine-induced acute hyperlocomotion are MOR-dependent. Tianeptine (0, 4, 8, 16, 32, and 64 mg/kg, in ascending order, subcutaneous injections) dose-dependently increased locomotor activity [left: representation of the distance (m) per 5-min bin, and right: average of the maximal distance (m) per 5-min bin]. *P's < 0.0001, vs. 0-mg/kg dose. N's = 10/group. (B–I) Mice were placed on locomotor activity boxes for 30 min for habituation, then tianeptine (0, 10, and 30 mg/kg, i.p.) was injected, and locomotor activity was recorded for 2 h on day 1 (B), day 4 (C), day 8 (D), day 11 (E), and day 15 (F). (G) Shows the total distance after tianeptine or saline injection over days. 30-mg/kg tianeptine-treated mice received extra sessions on days 16 (H) and 17 (I). *P's < 0.05 vs. SAL mice. &p < 0.05, vs. Day 1. #P's < 0.05, vs. days 4 and 8. $p < 0.05, vs. the first timepoint of the habituation period (0–15 min). N's = 8/group.