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. 2023 May 23;10:1206138. doi: 10.3389/fcvm.2023.1206138

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© 2023 Kühle, Cho, Barber, Goolaub, Darby, Morrison, Haller, Sun and Seed.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gadolinium imaging (left) and SSFP short-axis cine feature tracking analysis (right) in a fetal sheep model of myocardial infarction on the day of surgery and 6 days post-surgery in both injured and sham twins suggesting good correlation between regional myocardial dysfunction in the apical left ventricular lateral wall and evidence of myocardial infarction in the respective segments in early and late gadolinium enhancement imaging. Anterolateral ischemia was noted at day of surgery from apex to near-mid ventricle (top row; early gadolinium enhancement; white arrow) and there was regional myocardial dysfunction in apical segments as measured by decreased circumferential strain by feature tracking (top row; right). 6 days after the myocardial infarction surgery, injury was noted in similar regions (bottom row; late gadolinium enhancement; white arrow) and there was regional myocardial dysfunction in the same regions, overall showing good correlation between injury and regional dysfunction measured by regional circumferential strain by feature tracking. In both scans, the internal sham control (fetus B) remained asymptomatic and did not demonstrate any regional wall motion abnormalities.