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. 2023 May 23;14:1150705. doi: 10.3389/fimmu.2023.1150705

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Copyright © 2023 Blest and Chauveau

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Extracellular 2’3’-cGAMP transport. Schematic showing the mechanisms by which 2’3’-cGAMP can be transferred between cells. (A) Within viral particles. (B) Through gap junctions. (C) Import and export through LRRC8A:C heterodimers which are activated by hypotonicity and Sphingosine-1-phosphate (S1P). (D) Export through ABCC1. (E) Transport through the ATP gated pore P2X7. (F) Import through SLC19A1. (G) Import through SLC46A2. (H) 2’3’-cGAMP shuttling by LL-37. (I) 2’3’-cGAMP hydrolysis by ENPP1.