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. 2023 May 23;14:1189007. doi: 10.3389/fendo.2023.1189007

Figure 1.

Figure 1

Molecular features of Serpina3c (A) The Serpina3c gene contains five exons, The first exon of the Serpina3c gene does not encode amino acid residues, and the second, third, fourth, and fifth exons of the Serpina3c gene encode 212, 92, 50 and 63 amino acid residues, respectively. (B) Comparison and alignment of murine Serpina3c protein sequences with human SerpinA3 protein. Two identical residues are represented in dark blue. A homology of 59% is detected between the murine Serpina3c protein and human SerpinA3 protein. The red box represents the P1-P1’ bond, which is conserved between Serpina3c and SerpinA3. (C) Prediction 3D structure of Serpina3c protein. The amino acid sequences were derived from UniProt (https://www.uniprot.org/uniprotkb/P29621), and the 3D structure was predicted by AlphaFold (https://alphafold.ebi.ac.uk/entry/P29621). AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions below 50 pLDDT may be unstructured in isolation.