TABLE 1.
List of miR‐34a targets in the tumor microenvironment of various cancers.
| Cancer type | Immuno | Involved molecule | Involved target | Function | Reference |
|---|---|---|---|---|---|
| Breast cancer | TAM/M2 | IL‐6R | MCT‐1 | Reprograms EMT and macrophages as well as inhibits tumor progression | 12 |
| CD4+ T cell | CAPN6 | / | Regulates cellular activities associated with CD4+ T cell infiltration | 20 | |
| Gastric cancer | T, B, and NK cells | PD‐L1 | / | Suppresses the proliferation as well as the migration and invasion of tumor | 23 |
| Lung cancer | TAM | KLF4 | / | Modulation of macrophage polarization reverses the processes of tumorigenesis | 15 |
| macrophages and Treg cells | PD‐L1 | p53 | Regulates tumor immune evasion | 24 | |
| Glioma | MSCs | SIRT1 | p53, Cdkn1a, and Cdkn2c | Induces glioma cell senescence | 25 |
| Liver cancer | Treg cells | CCL22 | / | Promotes tumor cells to escape from immune surveillance | 26 |
| Head and neck squamous cell carcinoma | pro‐B cells, CD8 naïve T cells, Th1 cells | PD‐L1 | MET | Suppresses oncogenic MET and restores tumor immunity | 13 |