Figure 1.

Vaginal microbiome composition

Vaginal swabs collected from 315 women were analyzed by mass spectrometry-based metaproteomics and passed quality control criteria (dark-blue participant group). 3,280 bacterial proteins from 20 unique genera and 142 species were identified in this group. Vaginal swab and vaginal tissues collected from another 90 HIV-negative women were analyzed by mass spectrometry and passed quality control criteria (light-blue participant group). 522 bacterial proteins from 15 unique genera were identified in this second group. All 405 samples were clustered and designated microbiome profile groups 0–4. Bacterial functions were also annotated using the KEGG database and are shown in the bottom panel in the same order as in the microbiome grouping. See also Table S2.