Table 1. Distribution of unique mutations/unrelated families/patients in kinase domains of protein kinases.
| Kinase | Missense | Nonsense | Insertion | Deletion | Total |
|---|---|---|---|---|---|
| Protein tyrosine kinases | |||||
| Btk | 62/102/120 | 21/37/42 | 10/8/10 | 30/30/33 | 123/147/205 |
| FGFR3 | 6/41/43 | 1/1/1 | – | – | 7/42/44 |
| IRK | 12/15/22 | – | – | 1/2/2 | 13/17/24 |
| JAK3 | 1/1/1 | 1/1/1 | – | 1/1/1 | 3/3/3 |
| KIT | 8/10/13 | – | 1/2/2 | 2/2/4 | 11/14/19 |
| MET | 9/10/10 | – | – | – | 9/10/10 |
| NTRK1 | 6/6/8 | – | – | 1/2/4 | 7/8/12 |
| RET | 21/25/150 | 1/1/1 | – | – | 22/26/151 |
| ZAP | 1/1/1 | – | 1/2/2 | 1/1/1 | 3/4/4 |
| TIE2 | 1/2/65 | – | – | – | 1/2/65 |
| Protein serine/threonine kinases | |||||
| PAK3 | – | 1/1/4 | – | – | 1/1/4 |
| LKB1 | 9/9/9 | 6/6/6 | 6/8/8 | 2/2/2 | 23/25/25 |
| KIR3 | 4/4/18 | – | – | – | 4/4/18 |
| CDK4 | 3/13/16 | – | – | – | 3/13/16 |
| TGR2 | 5/5/5 | – | – | – | 5/5/5 |
| RSK2 | 7/7/7 | 6/6/6 | – | 3/3/3 | 16/16/16 |
| Total | 155/251/488 | 37/53/61 | 18/20/22 | 41/43/50 | 251/337/621 |