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. 2023 Apr 5;41(7):1159–1167. doi: 10.1097/HJH.0000000000003445

FIGURE 2.

FIGURE 2

Impact of hypertension and amlodipine treatment on cognitive function. (a) Spatial working memory was unaltered in BPH mice in the y-maze alternation task (t-test: ∗P < 0.05 vs. 50%; n = 8–10 per group). (b) The decrease in spatial short-term memory (d2 discrimination index) in BPH in the Object Location Task was prevented by amlodipine (2-W ANOVA Pint > 0.05; Ptime = 0.072; Pgroup < 0.01; Tukey's multiple comparison test: ∗∗P < 0.05 vs. BPH; n = 8–10 per group). (c--e) Spatial learning and long-term memory were assessed using the Barnes Maze Task. (c) At 8 months of age, the distance to escape was higher in BPH and BPH+A vs. BPN (2-W ANOVA Pint < 0.005; Ptime < 0.001; Pgroup < 0.001; Tukey's multiple comparison test: ∗P < 0.05. vs. BPN; n = 8–10 per group). (d) At 12 months of age, the distance to escape was higher in BPH and BPH+A vs. BPN on the first 2 days and the distance to escape was higher in BPH+A on day 1 vs. BPH (2-W ANOVA Pint < 0.005; Ptime < 0.005; Pgroup < 0.005; Tukey's multiple comparison test: ∗P < 0.05 vs. BPN; ∗∗P < 0.05 vs. BPH; n = 8–10 per group). (e) Long-term spatial memory as assessed by the time spent in the target quadrant during the probe trial, did not differ between groups (2-W ANOVA Pint > 0.05; Ptime > 0.05; Pgroup > 0.05; n = 8–10 per group).