Forest plots showing primary outcome (win ratio), heart failure event rate and change in Kansas City Cardiomyopathy Questionnaire (KCCQ) score based on the presence or absence of latent pulmonary vascular disease, presence or absence of permanent cardiac rhythm device (pacemaker) and presence or absence of left atrial (LA) enlargement. Reproduced from Borlaug et al.21
Abbreviations: HF, heart failure; HFpEF, heart failure with preserved ejection fraction; LA, left atrial; PVD, pulmonary vascular disease.