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The binding characteristic of FXR to the IR1 site. A: DNA matrix of the IR1 element. B: Occurrence of the IR1 binding motif in the FXR-binding sites. C: Binding features of FXR with IR1 in the absence of RXR or in the presence of RXR were determined by EMSA. D: DNA binding affinities of FXR and RXR to IR1 were measured by FPA.
