Table 2.

Significant association with SNP and survival outcome across cohorts

SAMHD1 SNPs	EFS		OS
	HR (95% CI)	P value	HR (95% CI)	P value
rs7265241 A>G	AML02 (n = 167)
Unadjusted analysis†	1.926 (1.046-3.547)	.035	2.410 (1.223-4.771)	.012
Risk-group adjusted analysis†	1.860 (1.010-3.428)	.046	2.235 (1.216-4.779)	.021
	AML08 (n = 233)
Unadjusted analysis†	1.264 (0.952-1.678)	.104	1.439 (1.043-1.986)	.027
Risk-group adjusted analysis†	1.823 (1.061-3.131)	.030	1.532 (1.042-1.987)	.010
	AAML1031 (n = 849)
Unadjusted analysis‡	2.722 (1.538-4.816)	.001	2.214 (1.253-3.912)	.006
Risk-group adjusted analysis‡	2.581 (1.458-4.567)	.001	1.202 (1.253-3.753)	.009
rs1291141 T>G	AML02 (n = 167)
Unadjusted analysis∗	1.204 (0.817-1.775)	.348	1.221 (0.772-1.933)	.393
Risk-group adjusted analysis∗	1.309 (0.881-1.947)	.183	1.396 (0.761-1.959)	.166
	AML08 (n = 233)
Unadjusted analysis‡	1.247 (0.911-1.707)	.167	1.548 (1.122-2.138)	.008
Risk-group adjusted analysis‡	1.160 (0.847-1.589)	.355	1.427 (1.122-2.139)	.031
rs1291128 T>C	AML02 (n = 163)
Unadjusted analysis†	0.932 (0.699-1.240)	.628	0.778 (0.564-1.073)	.126
Risk-group adjusted analysis†	0.859 (0.644-1.146)	.300	0.716 (0.563-1.075)	.043

MOI, mode of inheritance; MAF, minor allele frequency.

^∗additive

^†dominant

^‡recessive