. 2021 Sep 27;1(4):e12036. doi: 10.1002/jcv2.12036

TABLE 4.

Associations between depression polygenic score (PGS) and diagnoses of inflammatory bowel disease and its subtypes, and vice versa

Exposure PGS	Outcome diagnosis	Individuals with outcome diagnosis (N)	OR (95% CI)/SD	p	Nagelkerke pseudo‐R ²
Exposure PGS	Outcome diagnosis	Individuals with outcome diagnosis (N)	OR (95% CI)/SD	p	Null model	Full model	Difference
Depression	Inflammatory bowel disease	396	0.99 (0.80, 1.22)	0.914	0.130244	0.130263	0.000019
Depression	Crohn's disease	199	0.92 (0.70, 1.22)	0.568	0.108187	0.108911	0.000724
Depression	Ulcerative colitis	244	0.95 (0.72, 1.25)	0.725	0.106734	0.107045	0.000031
Inflammatory bowel disease	Depression	18,761	1.00 (0.98, 1.03)	0.803	0.328959	0.328963	0.000004
Crohn's disease	Depression	18,761	1.00 (0.98, 1.03)	0.779	0.328959	0.328964	0.000005
Ulcerative colitis	Depression	18,761	0.98 (0.95, 1.01)	0.219	0.328959	0.329054	0.000095

Note: Odds ratios (OR) with 95% confidence intervals (CI) per one standard deviation (SD) increase in PGS.