TABLE 1.
Child and parental characteristics by prenatal exposure to acetaminophen
| Unexposed N = 15,165 N (%) Median (range) | Exposed 1–7 days N = 7,988 N (%) Median (range) | Exposed 8–28 days N = 2,897 N (%) Median (range) | Exposed 29 days or more N = 563 N (%) Median (range) | |
|---|---|---|---|---|
| Maternal age | ||||
| <25 years | 1,411 (9.3%) | 776 (9.7%) | 237 (8.2%) | 37 (6.6%) |
| 25–34 years | 11,569 (76.3%) | 6,178 (77.3%) | 2,223 (76.7%) | 438 (77.8%) |
| >34 years | 2,185 (14.4%) | 1,034 (12.9%) | 437 (15.1%) | 88 (15.6%) |
| Missing information | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Maternal education | ||||
| Less than high‐school | 659 (4.4%) | 340 (4.3%) | 128 (4.4%) | 29 (5.2%) |
| High‐school | 3,193 (21.1%) | 1,758 (22.0%) | 661 (22.8%) | 122 (21.7%) |
| University/college | 10,464 (69.0%) | 5,498 (68.8%) | 1,977 (68.2%) | 387 (68.7%) |
| Missing information | 849 (5.6%) | 392 (4.9%) | 131 (4.5%) | 25 (4.4%) |
| Maternal smoking during pregnancy | ||||
| Yes | 683 (5.6%) | 450 (5.6%) | 155 (5.4%) | 48 (8.5%) |
| No | 13,959 (92.1%) | 7,356 (92.1%) | 2,695 (93.0%) | 503 (89.3%) |
| Missing information | 182 (2.3%) | 182 (2.3%) | 47 (1.6%) | 12 (2.1%) |
| Maternal alcohol use during pregnancy | ||||
| Yes | 1,387 (9.2%) | 856 (10.7%) | 334 (11.5%) | 73 (13.0%) |
| No | 11,430 (75.4%) | 6,049 (75.7%) | 2,208 (76.2%) | 423 (75.1%) |
| Missing information | 2,348 (15.5%) | 1,083 (13.6%) | 355 (12.3%) | 67 (11.9%) |
| Maternal symptoms of depression and anxiety (scale 1–4) | 1.19 (0.33) | 1.21 (0.34) | 1.25 (0.39) | 1.31 (0.45) |
| Missing information | 2.7% | 2.1% | 1.8% | 1.8% |
| Parity | ||||
| Primiparous | 6,087 (40.1%) | 2,876 (36.0%) | 808 (27.9%) | 120 (21.3%) |
| Parous | 9,044 (59.6%) | 5,097 (63.8) | 2,087 (72.0%) | 443 (78.7%) |
| Missing information | 34 (0.2%) | 15 (0.2%) | 2 (0.1%) | 0 (0%) |
| Child's birth year | 2005 (1999–2009) | 2005 (1999–2009) | 2006 (1999–2009) | 2006 (2000–2009) |
| Missing information | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
| Child's sex | ||||
| Boy | 7,906 (52.1%) | 4,066 (50.9%) | 1,447 (50.0%) | 278 (49.4%) |
| Girl | 7,214 (47.6%) | 3,899 (48.8%) | 1,448 (50.0%) | 285 (50.6%) |
| Missing information | 45 (0.3%) | 23 (0.3%) | 2 (0.1%) | 0 (0%) |
| Number of indications with pre‐pregnancy use | 0 (0–2) | 0 (0–3) | 0 (0–3) | 1 (0–3) |
| % yes | 9.0% | 31.7% | 45.8% | 55.6% |
| Number of indications with post‐pregnancy use 0–3 | 0 (0–0) | 0 (0–2) | 0 (0–3) | 0 (0–4) |
| % yes | 0% | 1.7% | 14.6% | 43.0% |
| Number of indications with post‐pregnancy use 4–6 | 0 (0–0) | 0 (0–2) | 0 (0–2) | 0 (0–3) |
| % yes | 0% | 1.4% | 13.7% | 38.4% |
| Number of co‐mediations | 0 (0–3) | 0 (0–7) | 0 (0–6) | |
| % yes | 8.5% | 23.3% | 42.8% | |
| ADHD diagnosis | 390 (2.6%) | 225 (2.8%) | 104 (3.6%) | 29 (5.2) |