Table 1.
TF mutation status in cancers from the Cbioportal database (www.cbioportal.org)
| Cancer type | Protein change | Mutation | Mutation type | COSMIC sample ID |
|---|---|---|---|---|
| Head and Neck Squamous Cell Carcinoma | F3-C11ORF80 | - | Fusion | TCGA-D6-6517–01 |
| F3-C11ORF80 | - | Fusion | TCGA-F7-A620-01 | |
| I70V | 1:g.95005817 T > C | Missense | TCGA-UF-A71A-01 | |
| X251_splice | 1:g.94997876C > T | Splice_Site | TCGA-CR-7399–01 | |
| Serous Ovarian Cancer | P238R | 1:g.94997915G > C | Missense | TCGA-23–2649-01 |
| K233N | 1:g.94997929C > A | Missense | TCGA-04–1648-01 | |
| Glioblastoma Multiforme | X71_splice | 1:g.95001720G > A | Splice_Region | TCGA-12–0775-01 |
| D93N | 1:g.95001656C > T | Missense | TCGA-19–5956-01 | |
| Lung Squamous Cell Carcinoma | S174R | 1:g.94998715G > C | Missense | TCGA-85–6560-01 |
| Y189C | 1:g.94998671 T > C | Missense | TCGA-56–8504-01 | |
| Bladder Urothelial Carcinoma | L274V | 1:g.94996084G > C | Missense | TCGA-XF-A8HE-01 |
| Uterine Endometrioid Carcinoma | G141R | 1:g.94998816C > T | Missense | TCGA-AX-A2HD-01 |
| C81F | 1:g.95001691C > A | Missense | TCGA-AP-A0LM-01 | |
| K181N | 1:g.94998694C > A | Missense | TCGA-D1-A17Q-01 | |
| E127D | 1:g.95001552C > A | Missense | TCGA-D1-A17Q-01 | |
| Q222H | 1:g.94997962 T > G | Missense | TCGA-BS-A0UV-01 | |
| L44* | 1:g.95005894A > C | Nonsense | TCGA-AX-A05Z-01 | |
| T87Rfs*3 | 1:g.95001672_95001673del | Frame_Shift_Del | TCGA-AX-A3FS-01 | |
| N170T | 1:g.94998728 T > G | Missense | TCGA-B5-A3FC-01 | |
| A112T | 1:g.95001599C > T | Missense | TCGA-B5-A3FC-01 | |
| E215* | 1:g.94997985C > A | Nonsense | TCGA-E6-A1LX-01 | |
| X251_splice | 1:g.94996151 T > C | Splice_Region | TCGA-EO-A22R-01 | |
| Lung Adenocarcinoma | L55* | 1:g.95005860_95005861del | Frame_Shift_Del | TCGA-05–4396-01 |
| N114Y | 1:g.95001593 T > A | Missense | TCGA-97-A4LX-01 | |
| Cutaneous Melanoma | N231T | 1:g.94997936 T > G | Missense | TCGA-EB-A24D-01 |
| E2K | 1:g.95007189C > T | Missense | TCGA-GN-A26C-01 | |
| V260I | 1:g.94996126C > T | Missense | TCGA-D9-A6EA-06 | |
| E94G | 1:g.95001652 T > C | Missense | TCGA-D9-A6EC-06 | |
| R168K | 1:g.94998734C > T | Missense | TCGA-D3-A8GM-06 | |
| S129F | 1:g.95001547G > A | Missense | TCGA-FR-A8YE-06 | |
| Diffuse Type Stomach Adenocarcinoma | F179Lfs*5 | 1:g.94998700del | Frame_Shift_Del | TCGA-CG-4465–01 |
| Tubular Stomach Adenocarcinoma | A200T | 1:g.94998030C > T | Missense | TCGA-HU-A4GQ-01 |
| L175I | 1:g.94998714G > T | Missense | TCGA-ZQ-A9CR-01 | |
| Colon Adenocarcinoma | S174N | 1:g.94998716C > T | Missense | TCGA-AA-3858–01 |
| Y135C | 1:g.95001529 T > C | Missense | TCGA-5 M-AAT6-01 | |
| Rectal Adenocarcinoma | N43D | 1:g.95005898 T > C | Missense | TCGA-AG-A002-01 |
| D177Y | 1:g.94998708C > A | Missense | TCGA-EI-6513–01 |
Its (*) part of mutation's name. The asterisk (*) is often used to denote a specific type of mutation called a stop codon mutation or a nonsense mutation. A stop codon is a specific sequence of DNA that signals the end of a protein-coding region. When a mutation occurs at this stop codon, it can result in a premature termination of protein synthesis