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. 2023 Mar 9;120(11):e2220767120. doi: 10.1073/pnas.2220767120

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Copyright © 2023 the Author(s). Published by PNAS.

This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 1. — Design and synthesis of double-click triazole libraries. (A) The structure and binding pocket of PF-06372222 as an initial template for the library design. The functional group to be replaced with 1,2,3-triazole is highlighted in green. (B) The structural representation of 10 triazole libraries (N1-N10). (C) The number of previously unknown azides in the 3,840-azide library according to the Reaxys database. (D) Double-click reaction sequence for generation of 10 triazole libraries using multiple azide pools prepared in microtubes (Route 1) or generation of a specific library N3 using individual azides prepared in microplates (Route 2).