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. 2023 May 23;14:1124245. doi: 10.3389/fneur.2023.1124245

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Copyright © 2023 Coyoy-Salgado, Orozco-Barrios, Sánchez-Torres, Olayo, Cruz, Morales-Corona, Olayo, Diaz-Ruiz, Ríos, Alvarez-Mejia, Mondragón-Lozano, Morales-Guadarrama, Alonso-García, Fabela-Sánchez and Salgado-Ceballos.

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Plasma-synthesized polypyrrole/iodine (PPy/I) and PPy/I plus swimming and enriched environment (PPy/I + SW/EE), treated groups promote changes in the gene expression profile of spinal cord injury (SCI). Venn's diagram was constructed by using the genes that changed their expression with the application of PPy/I and PPy/I + SW/EE treatments when compared with the untreated spinal cord injury group. PPy/I differentially regulated 82 genes while PPy/I + SW/EE regulated the expression of 84 transcripts. Volcano plot of differentially expressed genes (DEGs) between spinal cord injury (SCI) group without treatment and PPy/I or PPy/I + SW/EE treated groups. Volcano plot of DEGs screened on the basis of |logFC| > 2 and adjusted p-value < 0.05. The red points represent up-regulated genes, the green points represent down-regulated genes, and the gray points represent genes with no significant difference.