Table 5.
Preclinical locomotor activity evaluation.
| References | Year | Method | Severity | Type injury | Test | Time | Size | Sample | Pre | < 72 hr | 1–3 wks | 1–2 mo | 3–5 mo | 6–11 mo | 12–24 mo |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Namdar et al. (93) | 2020 | WD | Mild | Diffuse | Open Field | 10 mins | 60 × 60 cm | T:15; C:13 | - | - | |||||
| Homsi et al. (102) | 2010 | WD | Mild | Diffuse | Open Field | 60 mins | 19 × 11 cm | T/C: 10–12 | +++ | ++ | ++ | + | |||
| Bajwa et al. (103) | 2016 | CCI-CS | Mild | Diffuse | Open Field | 30 mins | 49 × 36 cm | T:10; C:10 | - | - | - | ||||
| McAteer et la. (106) | 2016 | WD | Mild | Diffuse | Open Field | 5 mins | 1 × 1 m | T:9; C: 9 | + | - | |||||
| Arulsamy et al. (108) | 2019 | WD | Mild | Diffuse | Open Field | 5 mins | 1 × 1 m | T:14; T:14 | - | ||||||
| Arun et al. (114) | 2020 | Blast | Mild | Blast | Open Field | 60 mins | 40 × 40 cm | T/C: 10–31 | - | - | - | - | + | - | |
| Feng et al. (89) | 2021 | Chimera | Rep-Mild | Diffuse 2 × 3 d |
Open Field | Unknown | 40 × 40 cm | T+C:81 | - | - | - | ||||
| Bajwa et al. (103) | 2016 | CCI-CS | Rep-Mild | Diffuse 2 × 3 d |
Open Field | 30 mins | 49 × 36 cm | T:10; C:10 | - | - | - | ||||
| Corrigan et al. (107) | 2017 | WD | Rep-Mild | Diffuse 3 × 5 d |
Open Field | 5 mins | 1 × 1 m | T/C: 8–10 | + | ||||||
| McAteer et al. (106) | 2016 | WD | Rep-Mild | Diffuse 3 × 5 d |
Open Field | 5 mins | 1 × 1 m | T:7; C: 9 | + | + | |||||
| Morriss et al. (104) | 2021 | WD | Rep-Mild | Diffuse 5x 24 hrs |
Open Field | Unknown | Unknown | T:11; C:10 | - | + | + | ||||
| Arulsamy et al. (108) | 2019 | WD | Rep-Mild | Diffuse 3 × 5 d |
Open Field | 5 mins | 1 × 1 m | T:14; C:14 | - | ||||||
| Arun et al. (114) | 2020 | Blast | Rep-Mild | Blast 2 × 2 mins |
Open Field | 60 mins | 40 × 40 cm | T/C: 10–31 | ++ | - | - | + | ++ | ++ | |
| Tucker et al. (105) | 2019 | CCI-CS | Rep-Mild | Diffuse 3x 24 hrs |
Open Field | 20 mins | 40 × 40 cm | T/C: 17–21 | - | +++ | +++ | +++ | |||
| Bajwa et al. (103) | 2016 | CCI | Moderate | Focal | Open Field | 30 mins | 49 × 36 cm | T:10; C:10 | - | +++ | - | ||||
| Leconte et al. (109) | 2020 | CCI | Moderate | Focal | Open Field | 9 mins | 1 m × 1 m | T:15; C:13 | + | ||||||
| Rowe et al. (111) | 2016 | LFP | Moderate | Mixed | Open Field | 5 mins | 70 × 70 cm | T/C:11–12: 2M | - | - | - | ||||
| T/C:11–12: 4M | - | - | |||||||||||||
| T/C:11–12: 6M | - | ||||||||||||||
| Arulsamy et al. (113) | 2018 | WD | Mod-Sev | Diffuse | Open Field | 5 mins | 1 x1 m | T:14; C:13 | - | + | |||||
| Arulsamy et al. (108) | 2019 | WD | Mod-Sev | Diffuse | Open Field | 5 mins | 1 x1 m | T:12; C: 14 | - | ||||||
| Islam et al. (110) | 2021 | CCI | Severe | Focal | Open Field | 5 mins | 54.5 × 54.5 cm | T,C: 9–13 | + | ||||||
| Komoltsev et al. (112) | 2021 | LFP | Severe | Mixed | Open Field | 5 mins | 1 × 1 m | T:13; C:7 | - |
+p < 0.05; ++p < 0.01; +++p < 0.001; -, not significant; Gray, not evaluated. T, TBI; C, control; CCI, control cortical impact; WD, weight drop injury; LFP, lateral fluid percussion injury.