Reduced deep white matter DTI metrics in children with ADHD + PAE compared to that in children with ADHD-PAE and TD children. The ADHD + PAE group showed significant (pfwe<0.05) reductions in all DTI metrics considered jointly (All), fractional anisotropy (FA), negative mean diffusivity (negMD; reverse coded for ease in presentation), and negative radial diffusivity (negRD) compared to those in the ADHD-PAE and TD groups (with the exception of FA). The mean FA skeleton is shown in green. Voxels with significance on both TD > ADHD + PAE and ADHD-PAE > ADHD + PAE are shown in cyan; voxels with significance on ADHD-PAE > ADHD + PAE only are shown in dark blue. ADHD, attention deficit hyperactivity disorder; PAE, prenatal alcohol exposure; TD, typically developing; DTI, diffusion tensor imaging.