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. Author manuscript; available in PMC: 2023 Jun 6.
Published in final edited form as: Semin Arthritis Rheum. 2023 Feb 11;59:152176. doi: 10.1016/j.semarthrit.2023.152176

Table 3.

Associations of all pre-diagnosis autoantibody sample concentrations among RA cases with serum anti-bacterial antibodies.

Unadjusted Adjusteda
Dependent Variable Anti-P. gingivalis coefficient (95% CI) p-value Anti-P. gingivalis coefficient (95% CI) p-value
Anti-CCP2 0.101 (−0.274,0.475) 0.597 0.105 (−0.274, 0.484) 0.586
ACPA against vimentin 0.020 (−0.180, 0.220) 0.845 0.032 (−0.170, 0.233) 0.758
ACPA against histone 0.168 (−0.027, 0.363) 0.092 0.173 (−0.024, 0.371) 0.085
ACPA against alpha- enolase 0.073 (−0.132, 0.277) 0.485 0.094 (−0.111, 0.299) 0.367
IgA RF − 0.066 (−0.244, 0.112) 0.465 −0.060 (−0.239, 0.119) 0.510
IgG RF 0.038 (−0.057, 0.133) 0.434 0.040 (−0.056, 0.137) 0.411
IgM RF 0.019 (−0.158, 0.195) 0.835 0.030 (−0.144, 0.205) 0.733
Dependent Variable Anti-P. intermedia coefficient (95% CI) p- value Anti-P. intermedia coefficient (95% CI) p-value
Anti-CCP2 1.838 (1.210, 2.466) <0.001 1.869 (1.235, 2.503) <0.001
ACPA against vimentin 0.792 (0.457, 1.127) <0.001 0.827 (0.490, 1.163) <0.001
ACPA against histone 0.739 (0.410, 1.068) <0.001 0.758 (0.426, 1.090) <0.001
ACPA against alpha-enolase 0.790 (0.443, 1.136) <0.001 0.840 (0.492, 1.187) <0.001
IgA RF 0.525 (0.236, 0.814) <0.001 0.536 (0.245, 0.827) <0.001
IgG RF 0.163 (0.002, 0.325) 0.047 0.163 (0.001, 0.326) 0.049
IgM RF 0.454 (0.157, 0.750) 0.003 0.442 (0.146, 0.737) 0.004
Dependent Variable Anti-F. nucleatum coefficient (95% CI) p-value Anti-F. nucleatum coefficient (95% CI) p-value
Anti-CCP2 0.066 (−0.326,0.459) 0.740 0.081 (−0.314,0.476) 0.687
ACPA against vimentin 0.055 (−0.154, 0.264) 0.604 0.048 (−0.161, 0.256) 0.655
ACPA against histone 0.036 (−0.169, 0.241) 0.731 0.041 (−0.165, 0.247) 0.693
ACPA against alpha-enolase 0.179 (−0.034, 0.392) 0.100 0.181 (−0.032, 0.393) 0.095
IgA RF − 0.090 (−0.275, 0.094) 0.337 −0.081 (−0.266, 0.104) 0.388
IgG RF 0.080 (−0.020, 0.179) 0.117 0.084 (−0.016, 0.184) 0.098
IgM RF − 0.046 (−0.231, 0.138) 0.622 −0.024 (−0.206, 0.158) 0.799

ACPA = anti-citrullinated protein antibodies.

All measures in this table were log base 2 transformed.

a

Models were adjusted for age, sex, and smoking.