Table 4.

Quantitative comparison of different synthesis-based and synthesis-free methods for whole glioma segmentation. ${}^{\#}$ and ${}^{\square }$ denote separated and end-to-end image synthesis and segmentation respectively. ${}^{▵}$ denotes synthesis-free methods for the segmentation task. Bold font highlights the best values obtained by synthesis-based methods. Results with no significant difference from the upper bound are denoted by *, according to a paired t-test (p-value $>$ 0.05).

Methods	Dice (%)	ASSD (mm)	HD95 (mm)
${}^{\#}$Pix2Pix [15]	84.67$\pm$7.93	2.26$\pm$2.09	9.12$\pm$ 11.97
${}^{\#}$PGAN [3]	85.79$\pm$7.73	1.90$\pm$1.29	7.21$\pm$7.53
${}^{\square }$PSCGAN [36]	86.45$\pm$8.04	1.99$\pm$1.59	8.62$\pm$9.62
${}^{\square }$ Wang et al. [32]	83.77$\pm$8.48	2.41$\pm$1.70	9.97$\pm$11.26
${}^{\square }$UAGAN$°$[41]	81.55$\pm$2.96	2.53$\pm$0.29	not reported
${}^{\square }$UAGAN [41]	86.27$\pm$8.10	1.96$\pm$1.37	8.04$\pm$8.47
${}^{▵}$w/o FLAIR	84.54$\pm$9.62	2.32$\pm$2.12	10.75$\pm$15.86
${}^{▵}$Real FLAIR	87.49$\pm$8.51	1.57$\pm$1.71	5.69$\pm$4.62
Ours	87.55$\pm$7.62${}^{\ast }$	1.53$\pm$0.85${}^{\ast }$	5.67$\pm$4.92${}^{\ast }$
${}^{▵}$Upper bound	88.65$\pm$10.01	1.50$\pm$1.89	5.54$\pm$4.69