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. Author manuscript; available in PMC: 2023 Sep 9.
Published in final edited form as: J Med Chem. 2023 Feb 24;66(5):3372–3392. doi: 10.1021/acs.jmedchem.2c01858

Scheme 2. Generic Synthesis of Class II (Compounds 31a–s and 32a–d)a.

Scheme 2.

aReagents and conditions: (a) NaH, THF, 0 °C to RT; (b) K2CO3, DMF, 80 °C; (c) bis(trimethylsilyl)-amide, THF, −78 °C ~ RT; (d) NH2OH or NH2NHCOCH3, pyridine, RT.