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Proposed mechanism for in vivo and/or in vitro metabolic degradation of an indole.33,34 Oxidation at the 3-position of the indole ring and its subsequent glycosylation results in its degradation. Alternatively, oxidation at the 3-position and subsequently at the 2-position leads to oxidative cleavage of the five-membered pyrrole constituent of the heterobicyclic ring by a cellular enzyme. Further oxidation results in degradation of the ring.
