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In vivo antagonism of AR by UT-155 (compound 8) and series 31 compounds. Growth of androgen-dependent organs in rats using an in vivoHershberger assay.21–24 Rats were treated orally (n = 5/group) for 14 d with 40 mg/kg/day of a vehicle, either indicated 31 series compounds or compound 8. Animals were sacrificed, and weights of prostate (A) and seminal vesicles (B) were measured and normalized to body weight. (C) Body Weight Difference.
