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. Author manuscript; available in PMC: 2023 Sep 9.
Published in final edited form as: J Med Chem. 2023 Feb 24;66(5):3372–3392. doi: 10.1021/acs.jmedchem.2c01858

Scheme 1. Generic Synthesis of Class I Compounds 27a–ea.

Scheme 1.

aReagents and conditions: (a) i. SOCl2, THF, 0 °C; ii. Et3N; (b) isatin, K2CO3, DMF, room temperature (RT); (c) NaH, THF, 0 °C to RT.