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. Author manuscript; available in PMC: 2023 Sep 9.

Published in final edited form as: J Med Chem. 2023 Feb 24;66(5):3372–3392. doi: 10.1021/acs.jmedchem.2c01858

Table 6.

In Vitro Metabolic Stability Of Class I, II, and III in Mouse Liver Microsomes (MLM)

		DMPK (MLM)^a				DMPK (MLM)^a
ID		T_1/2 (min)	CL_int (mL/min/mg)	ID		T_1/2 (min)	CL_int (mL/min/mg)
Class I	27b	41.77	1.66		35b	45.00	1.5
Class I	27c	39.94	1.735		35c	23.66	2.93
	31h	7.70	8.90	Class III	35d	49.46	1.4
	31i	23.44	2.96	Class III	35g	22.60	3.1
	31j	14.60	4.70		35h	105.00	0.66
	31l	55.00	1.30		35i	120.60	0.60
Class II	31o	50.15	1.40
	31q	12.63	5.5
	32a	13.29	5.2	8 ²²	Antagonist	12.35	5.614
	32c	53.71	1.29	1	Antagonist	10.04^b	86.3¹⁶
	32d	35.46	1.96	6	Agonist	360.00	1.4¹⁶

^a

Compounds were incubated with MLM and cofactors for phases I and II, as described in the Experimental Section.

^b

T_1/2 (h) as previously reported.^19,20