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. Author manuscript; available in PMC: 2023 Sep 9.
Published in final edited form as: J Med Chem. 2023 Feb 24;66(5):3372–3392. doi: 10.1021/acs.jmedchem.2c01858

Table 9.

Relative Abundance of Identified Metabolites for Compound 32c in Each Species

Peak areas (× 103)
M #a [M – H] − Mass Shift Human Rat Dog Monkey Mouse
M1 489.1054 34.9955 286***c 74.8***c 20.7***c 111 49.8
M2 489.1054 34.9955 254 NAb NA 150***c NA
M3 551.0460 192.0270 1122**c 583**c 36.0**c 839**c 52.7***c
M4 647.1287 192.0270 6147*c 3460*c 208*c 7131*c 1206*c
M5 471.0892 15.9949 28.5 NA 19.4 NA 1170**c
a

M #, Metabolite number.

b

NA, not assessed.

c

*, Most abundant metabolite in species; **, second most abundant; and ***, third most abundant.