Table 4.
Associations between moderately-elevated blood pressure during pregnancy, stratified by placental/placental membrane findings, and maternal blood pressure at follow-up (7–15 years after POUCH Study pregnancy) among women with no hypertensive disorders during the POUCH Study pregnancy (N=450)
Blood Pressure (BP)at follow-up (n=450) | |||||||
---|---|---|---|---|---|---|---|
Normal/Slightly Elevated BP (ref) |
Stage 1 Hypertension |
Stage 2 Hypertension |
|||||
<130 Systolic BP and <80 Diastolic BP |
130–139 Systolic BP and /or 80–89 Diastolic BP |
≥ 140 Systolic BP and /or ≥ 90 Diastolic BP or currently taking medications |
|||||
N (ref) | N | OR* | aOR# | N | OR* | aOR# | |
| |||||||
Blood Pressure in pregnancy and placental/extraplacental membrane findings | |||||||
Normal BP (ref) | 106 | 30 | 1.0 | 1.0 | 16 | 1.0 | 1.0 |
Moderately-elevated BP/ − Mural hyperplasia (0/7) | 155 | 46 | 1.1 (0.6, 2.0) | 1.0 (0.5, 2.1) | 36 | 1.5 (0.7, 3.2) | 1.6 (0.7, 3.6) |
Moderately-elevated BP/ + Mural hyperplasia (≥1/7) | 34 | 7 | 0.6 (0.2, 1.9) | 0.6 (0.2, 2.0) | 20 | 5.1 (2.1, 12.4) | 4.5 (1.6, 12.5) |
| |||||||
Normal BP (ref) | 106 | 30 | 1.0 | 1.0 | 16 | 1.0 | 1.0 |
Moderately-elevated BP/None or one (0–1/7) unaltered/abnormal decidual vessels | 99 | 27 | 1.0 (0.5, 2.0) | 1.0 (0.4, 2.2) | 19 | 1.3 (0.6, 3.1) | 1.6 (0.6, 4.1) |
Moderately-elevated BP/Two or more (≥2/7) unaltered/abnormal decidual vessels | 90 | 26 | 1.0 (0.5, 2.1) | 0.9 (0.4, 2.0) | 37 | 2.9 (1.3, 6.2) | 2.6 (1.1, 5.9) |
Weighted for the POUCH Study sub-cohort sampling scheme.
Adjusted for maternal race, maternal age at enrollment, interval of follow-up, smoking before pregnancy, and pre-pregnancy BMI at POUCH Study.