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. 2023 Apr 24;8(8):e166643. doi: 10.1172/jci.insight.166643

Figure 2. ABT-263 and FST inhibit renal interstitial fibrosis in post-RLDC mice.

Figure 2

C57BL/6 mice were subjected to RLDC treatment followed by 4-week treatment of ABT-263 (n = 13), FST (n = 8), or vehicle (n = 14). Control (CT) mice (n = 7) were injected with saline. Kidneys were harvested at 8 weeks for histology and immunohistochemical staining. (A) Representative images of Sirius Red/Fast Green staining. Scale bar: 100 μm. (B–D) Representative images of FN, COL1, and α-SMA staining. Scale bar: 50 μm. (E) Quantification of Sirius Red/Fast Green staining. (F–H) Quantification of FN, COL1, and α-SMA staining. Positive signals from blood vessels and glomeruli were excluded. Quantitative data are presented as mean ±SD. One-way ANOVA with multiple comparisons was used for statistics. *P < 0.05, **P < 0.01, ***P < 0.005, and ****P < 0.001.