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. 2023 Apr 24;8(8):e166044. doi: 10.1172/jci.insight.166044

Figure 1. Evaluation of the survival rates and levels of Plg and IL-6 in plasma of mice after severe and nonsevere sepsis.

Figure 1

C57BL/6J mice were subjected to severe (18G needle) and nonsevere (30G needle) CLP. (A) The survival rates (n = 6 mice) were monitored for 6 days. (B and C) The levels of Plg (B) and IL-6 (C) were measured in plasma by ELISA 12 hours after CLP. (D) The correlation between plasma Plg and IL-6 levels was evaluated by Pearson’s coefficients. Results are shown as the mean ± SEM of at least 5 mice per group. The experiments were performed 3 times with similar results. ***P < 0.001 when comparing sham with severe CLP groups. #P < 0.05 or ###P < 0.001 when comparing severe and nonsevere sepsis groups (1-way ANOVA with post hoc Newman-Keuls).