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. 2023 Jun 6:1–18. Online ahead of print. doi: 10.1007/s44174-023-00090-z

Table 10.

Summary of various salivary biosensors for systemic disease detection

Systemic diseases Salivary biomarkers Salivary biosensors References
Diabetes mellitus Glucose Salivary nanobiosensor Zhang et al. [106]
HIV Immunoglobulin Electrochemical peptide-based biosensors McQuistan et al. [107]
Cardiovascular diseases CRP, Lactate

Electro

chemiluminescence biosensor Microchip assay biosensor

Claver et al

[108]

Christodoulides et al

[109]

Breast cancer

ATP6AP1,

CA15-3, CEA,

CA125, HER-

2/neu

Quartz crystal biosensor Surface plasma resonance biosensor Multiplexed microfluidic biosensor

Arif et al. [53]

Liang et al. [110]

Jokerst et al. [111]

Hyperphosphatemia Phosphate Amperometric biosensor Kwan et al. [112]