Table 8.

Summary of salivary biomarkers found for Rheumatoid arthritis

Disease	Biomarkers	Sample type	Result	References
Rheumatoid arthritis	MMP-8	Serum and Saliva	MMP-8 is elevated in saliva at early stage of Rheumatoid arthritis	Äyräväinen et al. [51]
Rheumatoid arthritis	IL-1, TNF-alpha	Serum and Saliva	Anti-TNF alpha antibody therapy reduces levels of IL-1 and TNFalpha in Saliva	Mirrielees et al. [52]
Rheumatoid arthritis	IL-1 beta	Serum and GCF	Periodontal therapy significantly decreases DAS28 and IL-1 beta levels in Rheumatoid arthritis patient	Bıyıkoğlu et al. [103]
Rheumatoid arthritis	ACPA (Anti- citrullinated protein antibodies). Antiporphyromonas gingivalis	Serum and Saliva	Anti-porphyromonas gingivalis antibodies are associated with ACPA	Hitchon et al. [104, 105]