Table 2.
Group comparison of the concentrations of neurometabolite covariates in the ACC and MPFC
| (a) ACC | ||||||
|---|---|---|---|---|---|---|
| Non-TRS (n = 35) | TRS (n = 38) | Control (n = 19) | Test statistics | |||
| Mean (s.d.) | Mean (s.d.) | Mean (s.d.) | F | p | Post-hoc | |
| Uncorrected model | ||||||
| Glx/NAAx | 1.081 (0.23) | 1.27 (0.39) | 1.13 (0.19) | 4.06 | 0.021 | Non-TRS < TRS |
| Corrected model 1 | ||||||
| Glx/NAAx (estimated mean, s.e.) | 1.07 (0.04) | 1.29 (0.05) | 1.11 (0.07) | 5.17 | 0.008 | Non-TRS < TRS |
| Corrected model 2 | ||||||
| Glx/NAAx (estimated mean, s.e.) | 1.06 (0.05) | 1.25 (0.06) | 1.20 (0.10) | 3.60 | 0.032 | Non-TRS < TRS |
ACC, anterior cingulate cortex; MPFC, medial prefrontal cortex; TRS, treatment-resistant schizophrenia; Glx, total glutamate + glutamine; NAAx, N-acetylaspartate + N-acetyl aspartylglutamate; s.e., standard error; FSIQ, full-scale IQ.
Corrected model 1: adjusted for age and sex; pairwise comparison with Bonferroni correction.
Corrected model 2: adjusted for age, sex, smoking status, educational level, and FSIQ; pairwise comparison with Bonferroni correction.