Table 2.
Additional post-hoc analyses for alcohol (categorical, with additional adjustment and time-lag analysis) in relation to health-related quality of life and fatigue
(Coefficient values and 95 % confidence intervals)
| EORTC QLQ-C30 | CIS | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Global QoL (0–100) | Physical functioning (0–100) | Role functioning (0–100) | Social functioning (0–100) | SumSc (0–100) | Fatigue (0–100) | Fatigue (20–140) | Subjective fatigue (8–56) | Activity fatigue (3–21) | |||||||||||
| β | 95 % CI | β | 95 % CI | β | 95 % CI | β | 95 % CI | β | 95 % CI | β | 95 % CI | β | 95 % CI | β | 95 % CI | β | 95 % CI | ||
| Categorical analysis† | |||||||||||||||||||
| No alcohol consumption | –2·8* | –5·3, –0·3 | –3·7* | –5·7, –1·7 | –5·9* | –9·4, –2·3 | –3·9* | –6·5, –1·2 | –3·6* | –5·0, –2·2 | 5·5* | 2·6, 8·5 | 4·5* | 1·2, 7·8 | 2·0* | 0·4, 3·6 | 0·9 | 0·2, 1·7 | |
| Moderate alcohol consumption‡ | REF | REF | REF | REF | REF | REF | REF | REF | REF | ||||||||||
| Heavy alcohol consumption‡ | 1·4 | –1·2, 4·0 | 2·1* | 0·0, 4·2 | 3·1 | –0·7, 6·8 | 2·6 | –0·1, 5·4 | 1·3 | –0·2, –2·2 | –2·0 | –5·1, 1·1 | –3·8* | –7·3, –0·3 | –2·1* | –3·8, –0·4 | –0·6 | –1·4, 0·3 | |
| Additional adjustment for habitual alcohol intake | |||||||||||||||||||
| Alcohol (10g/d) | Adj. | 1·5* | 0·5, 2·5 | 1·4* | 0·7, 2·2 | 2·7* | 1·4, 4·1 | 1·5* | 0·5, 2·5 | 1·4* | 0·8, 1·9 | –2·2* | –3·3, –1·0) | –2·2* | –3·5, –0·9 | –1·3* | –1·9, –0·7 | –0·3* | –0·6, –0·0 |
| Within | 1·5* | 0·3, 2·7 | 1·5* | 0·6, 2·4 | 3·8* | 2·0, 5·7 | 1·6* | 0·3, 2·9 | 1·4* | 0·8, 2·1 | –2·2* | –3·6, –0·9 | –1·7* | –3·2, –0·2 | –1·1* | –1·9, –0·4 | –0·2 | –0·5, 0·1 | |
| Between | 1·5 | –0·1, 3·2 | 1·4 | –0·2, 3·0 | 1·3 | –0·8, 3·4 | 1·4 | –0·2, 3·0 | 1·2* | 0·0, 2·3 | –2·0 | –4·1, 0·0 | –3·6* | –6·2, 1·1 | –1·8* | –3·0, –0·6 | –0·5 | –0·9, 0·0 | |
| Time lag analysis | Unadj | 1·0* | 0·3, 1·8 | 0·5 | –0·1, 1·2 | 1·4* | 0·5, 2·5 | 0·6 | –0·1, 1·4 | 0·5 | –0·0, 0·9 | –1·4* | –2·3, –0·5 | –0·6 | –1·7, 0·5 | –0·3 | –0·8, 0·2 | –0·0 | –0·2, 0·2 |
| Alcohol (10g/d) | Adj.‡,§ | 0·9* | 0·2, 1·6 | 0·5 | –0·3, 1·3 | 1·3* | 0·2, 2·5 | 1·3* | 0·4, 2·3 | 0·4* | 0·1, 0·8 | –1·4* | –2·4, –0·4 | –0·8 | –2·0, 0·4 | –0·3 | –0·9, 0·2 | 0·0 | –0·2, 0·3 |
| Within | 0·4 | –1·1, 2·0 | –0·5 | –1·6, 0·5 | –0·4 | –2·6, 1·7 | –0·7 | –2·3, 0·8 | –0·5 | –1·3, 0·3 | –0·3 | –2·1, 1·5 | 1·4 | –0·5, 3·4 | 0·7 | –0·3, 1·6 | 0·3 | –0·1, 0·8 | |
| Between | 1·3* | 0·4, 2·3 | 0·7 | –0·2, 1·7 | 1·2* | 0·0, 2·4 | 1·3* | 0·4, 2·2 | 0·9* | 0·2, 1·5 | –1·8* | –3·0, –0·7 | –2·1* | –3·5, –0·6 | –0·9* | –1·6, –0·2 | –0·1 | –0·4, 0·2 | |
EORTC QLQ-C30, European Organization for the Research and Treatment of Cancer Quality of Life; β, beta-coefficient; QoL, quality of life; g/d, gram per day.
Indicates a statistically significant association.
Alcoholic consumption was modelled as a categorical variable: no alcohol consumption; moderate alcohol consumption: 1–14 glasses per week (reference category); and heavy alcohol consumption: > 14 glasses per week for both men and women.
Model adjusted for sex (male/female), age enrolment (years), co-morbidities (0, 1 and ≥ 2), weeks since end of treatment (weeks), chemotherapy (yes/no), BMI (kg/m2), moderate-to-vigorous physical activity (min/week), sedentary time (h/d), energy intake (kcal/d) and stoma (yes/no).
The beta-coefficients represent the overall longitudinal difference in the outcome score.